Selected publications

Kondratiuk I, Jakhanwal S, Jin J, Narayanan U, Kroppen B, Krisko A, Meinecke M, Asheri U, Jahn R, Fasshauer D, Milosevic I@ (2020) PI(4,5)P2-dependent regulation of exocytosis by amisyn, a vertebrate-specific competitor of synaptobrevin 2. Proc Natl Acad Sci USA 201908232. doi: 10.1073/pnas.1908232117. Online ahead of print.

Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, Maritzen T, Haucke V, Raimundo N, Sørensen JB, Milosevic I@ (2020) Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin. Nat Commun 2020 Mar 9; 11(1):1266.

Fonseca TB, Sánchez-Guerrero A, Milosevic I@, Raimundo N@ (2019) Mitochondrial fission requires Drp1 but not dynamins. Nature 570(7761):E34-E42, doi: 10.1038/s41586-019-1296-y

Gowrisankaran S, Morgan DG, Milosevic I, Mim C (2019) Cells control BIN1-mediated membrane tubulation by altering the membrane charge. J Mol Biol S0022-2836(19)30698-9

Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West P, Raimundo N (2019) Impaired lysosomal acidification triggers iron deficiency, necrotic cell death and inflammation in vivo. eLife 8, pii: e51031, doi: 10.7554/eLife.51031

Kroll J, Özçete ÖD, Jung S, Maritzen T, Milosevic I, Wichmann C, Moser T (2019) AP180 promotes release site clearance and clathrin-dependent vesicle reformation in inner hair cells of the mouse cochlea. J Cell Sci 133(2):jcs236737.

Kroll J, Jaime Tobón LM, Vogl C, Neef J, Kondratiuk I, König M, Strenzke N, Wichmann C@, Milosevic I@, Moser T@ (2019) Endophilin-A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells. EMBO J 38(5). doi: 10.15252/embj.2018100116.

Yambire KF, Fernandez-Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, Raimundo N (2019) Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. eLife. Feb 18;8. pii: e39598. doi: 10.7554/eLife.39598

Fernandez-Mosquera L, Yambire KY, Couto R, Pereyra L, Stagi M, Milosevic I, Raimundo N (2019) Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis. Autophagy 1-20, doi: 10.1080/15548627.2019

Watanabe S, Mamer LE, Raychaudhuri S, Luvsanjav D, Eisen J, Trimbuch T, Söhl-Kielczynski B, Fenske P, Milosevic I, Rosenmund C, Jorgensen EM (2018) Synaptojanin and endophilin mediate neck formation during ultrafast endocytosis. Neuron 98(6), 1184-1197

Farsi Z, Gowrisankaran S, Matija K, Rammner B, Woehler A, Mim C, Jahn R, Milosevic I (2018) Clathrin coat controls vesicle acidification by blocking vacuolar ATPase activity. eLife 7, doi: 10.7554/eLife.32569

Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Piqué A; Branco Fonseca T; Fernandez CO, Milosevic I, Outeiro TF (2018) Membrane binding is required for the internalization and RAB protein-mediated sorting and processing of α-synuclein in the cell. Acta Neuropathol Commun, 6(1):79

Rostosky CM, Milosevic I (2018) Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration. J Vis Exp 136, doi: 10.3791/57752

Llorens F, Thüne K, Tahir W, Kanata E, Diaz-Lucena D, Xanthopoulos K, Kovatsi E, Pleschka C, Garcia-Esparcia P, Schmitz M, Ozbay D, Correia S, Correia A, Milosevic I, Andréoletti O, Vorberg IM, Glatzel M, Sklaviadis T, Torres JM, Krasemann S, Sánchez-Valle R, Ferrer I, Zerr I. (2017) YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias. Mol Neurodegener 12(1), 83

Fiuza M, Rostosky C, Parkinson G, Bygrave A, Halemani N, Baptista M, Milosevic I, Hanley J (2017) PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin. J Cell Biol 216(10), 3323-3338

Peric M, Lovric A, Saric A, Musa M, Bou Dib P, Rudan M, Nikolic A, Sobocanec S, Mikecin AM, Dennerlein S, Milosevic I, Vlahovicek K, Raimundo N, Krisko A (2017) TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan. Aging Cell 16(5), 994-1005

Fernández-Mosquera L, Diogo CV, Yambire KF, Santos GL, Luna Sánchez M, Bénit P, Rustin P, Lopez LC, Milosevic I, Raimundo N (2017) Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis. Sci Rep 7, 45076

Murdoch JD, Rostsoky C, Gowrisankaran S, Arora AS, Soukup SF, Vidal R, Capece V, Freytag S, Fischer A, Verstreken P, Bonn S, Raimundo N, Milosevic I@ (2016) Endophilin-A deficiency induces the FoxO3a-Fbxo32 network in the brain and causes dysregulation of autophagy and the ubiquitin-proteasome system. Cell Rep 17(4), 1071-1086

Villar-Piqué A, Fonseca TL, Sant’Anna R, Fonseca-Ornelas L, Pinho R, Masaracchia C, Szegö EM, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF (2016) Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. PNAS USA 113(42), E6506-15

Pechstein A, Gerth F, Milosevic I, Jäpel M, Eichhorn-Grünig M, Vorontsova O, Bacetic J, Maritzen T, Shupliakov O, Freund C, Haucke V (2015) Vesicle uncoating regulated by SH3-SH3 domain-mediated complex formation between endophilin and intersectin at synapses. EMBO Rep 16(2), 232-239

Cao M, Milosevic I, Giovedi S, De Camilli P (2014) Upregulation of Parkin in endophilin mutant mice. J Neurosci 34(49), 16544-16549

Shen H, Giordano F, Wu Y, Chan J, Zhu C, Milosevic I, Wu X, Yao K, Chen B, Baumgart T, Sieburth D, De Camilli P (2014) Coupling between endocytosis and sphingosine kinase 1 recruitment. Nat Cell Biol 16 (7), 652-62

Giordano F, Saheki Y, Idevall-Hagren O, Colombo SF, Pirruccello M, Milosevic I, Gracheva EO, Bagriantsev SN, Borgese N, De Camilli P (2013) PI(4,5)P2-dependent and Ca2+-regulated ER-PM interactions mediated by the extended synaptotagmins. Cell 153 (7), 1494-509

Soda K, Balkin DM, Ferguson SM, Paradise S, Milosevic I, Giovedi S, Volpicelli-Daley L, Tian X, Wu Y, Ma H, Son SH, Zheng R, et al. (2012) Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin Invest 122 (12), 4401-4411

Milosevic I, Giovedi S, Lou X, Raimondi A, Collesi C, Shen H, Paradise S, O’Toole E, Ferguson S, Cremona O, De Camilli P (2011) Recruitment of endophilin to clathrin coated pit necks is required for efficient vesicle uncoating after fission. Neuron 72 (4), 587-601

de Wit H, Walter A, Milosevic I, Gulyás-Kovács A, Sørensen JB, Verhage M (2009) Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell 138 (5), 935-946

Nagy G, Milosevic I, Mohrmann R, Wiederhold K, Walter AM, Sørensen JB (2008) The SNAP-25 linker as an adaptation toward fast exocytosis. Mol Biol Cell 19 (9), 3769-3781

Gulyás-Kovács A, de Wit H, Milosevic I, Kochubey O, Toonen R, Klingauf J, Verhage M & Sørensen JB (2007) Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming. J Neurosci 27 (32), 8676-8686

Sørensen JB, Wiederhold K, Müller M, Milosevic I, Nagy G, de Groot B, Grubmüller H, Fasshauer D (2006) Sequential N- to C-terminal „zipping-up“ of the SNARE complex drives priming and fusion of secretory vesicles. EMBO J 25 (5), 955-966

Nagy G, Milosevic I, Fasshauer D, Müller M, de Groot B, Lang T, Wilson MC, Sørensen JB (2005) Alternative splicing of SNAP-25 regulates secretion through non-conservative substitutions in the SNARE domain. Mol Biol Cell 16, 5675-85

Milosevic I, Sørensen JB, Lang T, Krauss M, Nagy G, Haucke V, Jahn R, Neher E (2005) Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells. J Neurosci 25 (10), 2557-65

@ equal contribution

Books and reviews

Gowrisankaran S, Milosevic I (2020) Regulation of synaptic vesicle acidification at the neuronal synapse. IUBMB Life 10.1002/iub.2235.

Chanaday N, Cousin M, Milosevic I, Watanabe S, Morgan JR (2019) The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms. J Neurosci 39(42), 8209-8216.

Milosevic I (2018) Spatial and temporal aspects of phosphoinositides in endocytosis studied in the isolated plasma membranes. In Methods Molecular Biology: Clathrin-Mediated Endocytosis, Volume 1847:147-160; Editor L Swan, Springer ISBN 978-1-4939-8717-7

Milosevic I (2018) Revisiting the role of clathrin-mediated endoytosis in synaptic vesicle recycling. Front Cell Neurosci 12:27

Milosevic I, Sørensen JB (2015) Fusion machinery: SNARE protein complex. In: Presynaptic terminals: p.87-127; Editor S. Mochida, Springer ISBN 978-4-431-55166-2

Milosevic I (2015) Endocytic machinery at the neuronal synapse. In: Presynaptic terminals: p.223-256, Editor S. Mochida, Springer ISBN 978-4-431-55166-2

Milosevic I, Raimundo N (2007) Genomics, Proteomics and Bioinformatics. Yale J Biol Med 80, 215-216